Recent progress in the treatment of sickle cell disease: an up-to-date review

Abstract Background Sickle cell disease is a fatal systemic condition characterized by acute painful episodes, persistent anemia, ongoing organ damage, infarction, and markedly shorter average lifetime. It first appeared in the tropics' malarial zones, where carriers benefit from an evolutionary advantage being shielded malaria death. Due to demographic shifts, this crisis now affects people all over world. In higher-income areas, such as vast swaths of Europe North South America, more children are born with syndrome. Main body Over last 10 years, clearer knowledge change fetal adult hemoglobin has evolved. Further investigation into chimerism, genomics, mixed gene editing, therapeutic reactivation produced very promising findings. Between 2017 2019, three innovative medications for sickle were approved FDA thanks previous advances, while many treatments under development. Short conclusion To improve patient outcomes, various that created late 1990s utilized treat examined study. our appraisal, we'll also focus on most important developments decade.